Over 25,000 vaccinations have been administered at the centre in Cavan.
The HSE says staff there passed the milestone last Friday.
Great turn out from the people of Cavan. Tremendous team effort from everyone involved in making this happen - vaccinators, admin, support staff, security, ICT, cleaning and Management Team. #HSELive pic.twitter.com/UgpnR95Jd1
— HSE Community Healthcare Organisation (CHO) Area 1 (@HSECommHealth1) July 12, 2021
4,600 vaccines were administered in the Hotel Kilmore centre last week, which is also the highest weekly total there.
The local centres at the Hotel Kilmore and Hillgrove Hotel opened for the full rollout in April.