AIB is planning to cut 1,500 jobs by 2023.
The bank also plans to vacate three head offices in Dublin in the next few years.
AIB says it plans to reduce its workforce by 1,500 by 2023 through retirements, natural exits and voluntary redundancies.
A severance scheme will be reopened in 2021 after it was paused earlier this year.
The bank says since the outbreak of COVID-19, 80 percent of their staff have been working from home and, as a result, as reassessed its head office requirements.
It has already completed the exit from its former headquarters in Ballsbridge and will also leave Hume House at the end of December.
It's also planning to leave three of its six remaining head office locations in Dublin as leases come up for renewal.
The Financial Services Union is calling for the decision to be delayed, saying there should not be job cuts in the middle of a pandemic.